Reaction of methylcerium reagent with tertiary amides: Synthesis of saturated and unsaturated ketones from tertiary amides
1998; Elsevier BV; Volume: 39; Issue: 27 Linguagem: Inglês
10.1016/s0040-4039(98)00959-9
ISSN1873-3581
Autores Tópico(s)Chemical Synthesis and Analysis
ResumoThe reaction of CeCl3•MeLi to tertiary amides has been studied. The reagent prepared from cerium(III) chloride and methyllithium at 0 °C adds cleanly to morpholine amides to give the corresponding methyl ketones. Even in the presence of a large excess of the reagent, no tertiary alcohol formation is observed, indicating that the tetrahedral intermediates are stable under the reaction conditions employed.
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