T1195 Ulcerative Colitis in a South-European Country. A National Perspective
2008; Elsevier BV; Volume: 134; Issue: 4 Linguagem: Inglês
10.1016/s0016-5085(08)62353-7
ISSN1528-0012
AutoresFrancisco Portela, Fernando Magro, Paula Lago, José Cotter, Isabelle Cremers, João Deus, Ana Vieira, H. Lopes, Paulo M. Caldeira, Luísa Leite Barros, Jorge dos Reis, Laura Carvalho, Raquel Gonçalves, Mário Júlio Campos, Paula Ministro, Maria Antónia Duarte, Luís Azevedo, Altamiro Costa‐Pereira,
Tópico(s)Diagnosis and treatment of tuberculosis
ResumoBackground: Previous studies have reported that inflammatory bowel disease (IBD), both Crohn's disease (CD) and ulcerative colitis (UC) are more common in urban areas, probably related to some characteristics of urban lifestyle.Influence of living in urban or rural areas in the severity of IBD is unknown.We hypothesized that living in urban areas may be associated to a more severity in IBD patients.Aim: We aimed at evaluating whether IBD patients from urban areas have a more aggressive illness.Methods: We conducted an observational study of all IBD patients (n=1225) followed in four tertiary centers over a 1year period in a very homogeneous region with similar distribution of the population in urban and rural areas.Urban patients were defined as those living in towns of more than 10,000 inhabitants, and rural patients were all those living in towns of 10,000 inhabitants or less.We assessed severity of the disease as surgical resection, steroid-dependency, steroidresistance, treatment with immunosuppressive drugs or biological therapies.Statistical analyzes were performed using logistic regression and Mann-Whitney tests as appropriate.Results: 1225 consecutive IBD patients, 684 (56%) CD and 541 (44%) UC, 629 (51%) male and 596 (49%) female, mean age 43 years, 677 (55%) from rural and 541 (45%) from urban were included.We found no relationship between patients place of residence and a more severe disease, neither considering all IBD patients together (p=0.17)not CD (p=0.49) or UC patients (p=0.75)considered separately.None of the parameters of severity analyzed (surgical resection, steroid-dependency, steroid-resistance, treatment with immunosuppressive drugs and biological therapies) were associated to rural or urban place of residence of patients.Conclusion: IBD patients living in urban areas don't develop a more severe illness.No differences were found between CD and UC patients.
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