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Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A

2013; Elsevier BV; Volume: 121; Issue: 15 Linguagem: Inglês

10.1182/blood-2012-06-436782

1528-0020

Der‐Cherng Liang, Hsi‐Che Liu, Chao‐Ping Yang, Tang‐Her Jaing, Iou‐Jih Hung, Ting‐Chi Yeh, Shih‐Hsiang Chen, Jen‐Yin Hou, Ying‐Jung Huang, Yu‐Shu Shih, Yu-Hui Huang, Tung‐Huei Lin, Lee‐Yung Shih,

Chronic Myeloid Leukemia Treatments

Key Points A comprehensive study of 19 gene mutations and their cooperation, including the first report of ASXL1 and TET2 mutations in pediatric AML. The development of pediatric AML requires fewer gene mutations than adult AML.