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HIV Type 1 Gag as a Target for Antiviral Therapy

2011; Mary Ann Liebert, Inc.; Volume: 28; Issue: 1 Linguagem: Inglês

10.1089/aid.2011.0230

1931-8405

Abdül Waheed, Eric O. Freed,

Cytomegalovirus and herpesvirus research

The Gag proteins of HIV-1 are central players in virus particle assembly, release, and maturation, and also function in the establishment of a productive infection. Despite their importance throughout the replication cycle, there are currently no approved antiretroviral therapies that target the Gag precursor protein or any of the mature Gag proteins. Recent progress in understanding the structural and cell biology of HIV-1 Gag function has revealed a number of potential Gag-related targets for possible therapeutic intervention. In this review, we summarize our current understanding of HIV-1 Gag and suggest some approaches for the development of novel antiretroviral agents that target Gag.