Portal de Periódicos da CAPES

Isolation and structure determination of enzymatically formed styrene oxide glutathione conjugates

1979; Elsevier BV; Volume: 27; Issue: 2-3 Linguagem: Inglês

10.1016/0009-2797(79)90134-0

1872-7786

J Pachecka, Pierluigi Gariboldi, L Cantoni, G. Belvedere, E. Mussini, Mario Salmona,

Eicosanoids and Hypertension Pharmacology

When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, two conjugates were formed. Structural investigation by mass spectrometry (MS), proton magnetic resonance (PMR) analysis and chemical fragmentation showed the presence of two positional isomers, namely S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in a ratio of approx. 60 : 40.