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Mortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort.

1995; National Institute of Environmental Health Sciences; Volume: 103; Issue: 6 Linguagem: Inglês

10.1289/ehp.95103598

1552-9924

Elizabeth M. Ward, J.M. Fajen, Avima M. Ruder, Robert A. Rinsky, William Halperin, Cynthia A. Fessler‐Flesch,

Carcinogens and Genotoxicity Assessment

Research ArticleOpen AccessMortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort. E M Ward, J M Fajen, A M Ruder, R A Rinsky, W E Halperin, and C A Fessler-Flesch E M Ward Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. , J M Fajen Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. , A M Ruder Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. , R A Rinsky Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. , W E Halperin Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. , and C A Fessler-Flesch Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. Published:1 June 1995https://doi.org/10.1289/ehp.95103598Cited by:34AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit AbstractThe International Agency for Research on Cancer has given the designations of "sufficient evidence" of carcinogenicity of 1,3-butadiene in experimental animals and "limited evidence" of carcinogenicity in humans. To investigate the carcinogenic effect in humans, we conducted a cohort mortality study among 364 men who were assigned to any of three 1,3-butadiene production units located within several chemical plants in the Kanawha Valley of West Virginia, including 277 men employed in a U.S. Rubber Reserve Plant which operated during World War II. The butadiene production units included in this study were selected from an index developed by the Union Carbide Corporation, which listed for each chemical production unit within their South Charleston, West Virginia and Institute, West Virginia, plants all products, by-products, and reactants. Departments included in the study were those where butadiene was a primary product and neither benzene nor ethylene oxide was present. A total of 185 deaths were observed; the standardized mortality ratio (SMR) for all causes of death was 91, reflecting lower mortality among the study population than the U.S. population. The study found a significantly elevated standardized mortality ratio (SMR) for lymphosarcoma and reticulosarcoma based on four observed cases (SMR = 577; 95% CI = 157-1480), which persisted in an analysis using county referent rates. An excess of lymphosarcoma and reticulosarcoma among all workers and among workers with routine exposure to 1,3-butadiene was also observed in the only other cohort of 1,3-butadiene production workers previously studied.(ABSTRACT TRUNCATED AT 250 WORDS)FiguresReferencesRelatedDetailsCited By Leso V, Capitanelli I, Lops E, Ricciardi W and Iavicoli I (2016) Occupational chemical exposure and diabetes mellitus risk, Toxicology and Industrial Health, 10.1177/0748233715624594, 33:3, (222-249), Online publication date: 1-Mar-2017. Vijayakumar S and Rajakumar B (2017) Experimental and Theoretical Investigations on the Reaction of 1,3-Butadiene with Cl Atom in the Gas Phase, The Journal of Physical Chemistry A, 10.1021/acs.jpca.6b12227, 121:9, (1976-1984), Online publication date: 9-Mar-2017. 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