Immunization of monkeys with rabies ribonucleoprotein (RNP) confers protective immunity against rabies
1991; Elsevier BV; Volume: 9; Issue: 2 Linguagem: Inglês
10.1016/0264-410x(91)90270-g
ISSN1873-2518
AutoresM. Tollis, B DIETSCHOLD, C VOLIA, Hilary Koprowski,
Tópico(s)Bacillus and Francisella bacterial research
ResumoThe ability of rabies virus ribonucleoprotein (RNP) to induce protective immunity against rabies and to prime for production of virus-neutralizing antibodies (VNA) was studied in monkeys. Following two immunizations with RNP, monkeys developed a strong anti-RNP response and were protected against a challenge infection with a lethal dose of street rabies virus. Monkeys that were primed with RNP and then immunized with a single dose of human diploid cell vaccine (HDCV) developed VNA titres comparable to the VNA titres in non-primed monkeys after a second HDCV immunization. The utility of rabies RNP for the pre-exposure prophylaxis of human rabies is discussed.
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