Long-term treatment of endogenous depression with nortriptyline with control of plasma levels
1974; Cambridge University Press; Volume: 4; Issue: 2 Linguagem: Inglês
10.1017/s0033291700042008
ISSN1469-8978
AutoresP. Kragh‐Sørensen, C. Eggert Hansen, Niels‐Erik Larsen, J Naestoft, Eigill F. Hvidberg,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoSYSNOPSIS The study was undertaken in order to clarify the clinical pharmacological basis for a correct design of controlled trials of the prophylactic effect of tricyclic antidepressants. Twenty-two patients, successfully treated with nortriptyline (NT) in hospital for endogenous depression, continued the treatment for up to five months in the outpatient clinic. Plasma levels of NT were checked, and ratings were performed regularly. Depressive relapses, all related to low plasma levels of NT, were seen in three patients. The gas Chromatographic method, described in detail, has proved suitable for clinical routine and the results demonstrate the value of monitoring plasma levels in achieving therapeutic control.
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