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Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro

2011; Elsevier BV; Volume: 82; Issue: 5 Linguagem: Inglês

10.1016/j.fitote.2011.03.006

1873-6971

Divya Lakshmanan, Jim Werngren, Leny Jose, K.P. Suja, Mangalam S. Nair, R. Luxmi Varma, Sathish Mundayoor, Sven Hoffner, R. Ajay Kumar,

Phytochemistry and Bioactivity Studies

Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA), EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242–0.485 mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.