Structure of alahopcin(nourseimycin), a new dipeptide antibiotic.
1985; Springer Nature; Volume: 38; Issue: 3 Linguagem: Inglês
10.7164/antibiotics.38.302
ISSN1881-1469
AutoresSatoshi Horii, Hiroshi Fukase, Eiji Higashide, Masahiko Yoneda, Hiroyuki Nishida, Heiichi Sakai, Akira Hirota, Akira Isogai,
Tópico(s)Marine Sponges and Natural Products
ResumoThe structure of alahopcin (nourseimycin) (1), a new dipeptide antibiotic isolated from Streptomyces, has been established to be (2S, 3R)-2-[(L-alanyl)amino]-4-formyl-3-(hydroxy-aminocarbonyl)butyric acid. 1 exists in two cyclic hemiacetal type tautomers formed by intramolecular ring closure between the hydroxyamino group and the formyl group in aqueous solution. The structure of the new weakly acidic amino acid (2), a constituent of 1, is revealed to be (2S, 3R)-2-amino-4-formyl-3-(hydroxyaminocarbonyl)butyric acid, and 2 also exists in two cyclic hemiacetal type tautomers in aqueous solution.
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