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Finding NEMO: genetic disorders of NF-κB activation

2003; American Society for Clinical Investigation; Volume: 112; Issue: 7 Linguagem: Inglês

10.1172/jci19960

1558-8238

Jordan S. Orange, Raif S. Geha,

interferon and immune responses

The pathways between a receptor and transcriptional activation mediated by NF-κB are complex. The study of human gene mutations that result in dysregulation of these pathways has provided insight into the functions of individual components of the pathway, their interrelations, and the significance of these systems to the organism .