Portal de Periódicos da CAPES

Bilateral fronto-occipital polymicrogyria and epilepsy

2001; Elsevier BV; Volume: 10; Issue: 4 Linguagem: Inglês

10.1053/seiz.2000.0496

1532-2688

Renée Ribacoba Montero, C Garcia Pravia, Aurora Astudillo, Javier Salas Puig,

Fetal and Pediatric Neurological Disorders

We present a clinico-pathological case report in which both cortical dysplasia and epilepsy coexisted: a 30 year old male who was dead on arrival at hospital. One and a half hours earlier he had developed complex partial status with peri-oral cyanosis. At post mortem examination his brain showed bilateral occipital frontal polymicrogyria with unlayered neuronal migration disorder; in other parts there were fourth layer migration disorders. The white matter exhibited multicystic encephalopathy. In the heart there was chronic interstitial and perivascular fibrosis, although he died of a cardiac arrest. Bilateral frontal-occipital polymicrogyria is highly epileptogenic. This was a sporadic case and we cannot define a clear aetiology. There was a pathological cardiac condition without previous vascular risk factors which might be related to repetition of seizures and possibly to his sudden death during status epilepticus.