Produção Nacional
Revisado por pares
Corrigendum to “Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171” [Epilepsy Behav 2006;8:635–42]
2007; Elsevier BV; Volume: 12; Issue: 1 Linguagem: Inglês
10.1016/j.yebeh.2007.07.006
ISSN1525-5069
AutoresÉrica R. Coimbra, Karinne Rezek, Sara Escorsi‐Rosset, Michele Christine Landemberger, Rosa Maria R.P.S. Castro, Michelle Nave Valadão, Ricardo Guarnieri, Tonicarlo Rodrigues Velasco, Vera C. Terra, Marino M. Bianchin, Lauro Wichert‐Ana, Veriano Alexandre, Helena Brentani, Vilma R. Martins, Américo Ceiki Sakamoto, Roger Walz,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoIn our article we described the lack of association between cognitive performance of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) and the presence of single-nucleotide polymorphisms (SNPs) at codons 129 and 171 of the cellular prion protein gene (PRNP).Unfortunately, a second researcher in our group was unable to reproduce a portion of these data when reevaluating 90% of the patient samples. The present results indicate that the prevalence of the variant allele N171S is 2.2% (2 cases in 90), which makes statistical analysis of the association between cognitive performance and 171 SNPs impracticable.The association between cognitive performance and codon 129 SNP is presented in Table 1. There was a trend toward lower performance on tests of similarities, arithmetic, vocabulary, and the Rey Visual Design Learning Test (RVDLT) in patients with the variant allele M129V or V129V when compared with those presenting M129M. In Table 2, Table 3, we describe the covariables that could be associated with the performance on these cognitive tests.Table 1Cognitive performance and PRNP SNPs at codon 129Cognitive testAll patientsSNP at codon 129P valueaP values were determined by ANOVA.M129MM129VV129VComprehension(n = 86)(n = 43)(n = 31)(n = 12) Mean (SD)7.7 (2.4)8.1 (2.1)7.35 (2.7)7.1 (2.2) Median (quartile range)7.0 (6.0–9.2)8.9 (7.0–10.0)7.0 (6.0–9.0)7.0 (5.2–9.5)0.25Similarities(n = 85)(n = 44)(n = 30)(n = 11) Mean (SD)7.2 (2.2)7.7 (2.4)6.6 (2.0)6.0 (1.8) Median (quartile range)7.0 (5.5–9.0)7.5 (6.0–9.0)6.5 (5.0–8.0)6.0 (6.0–8.0)0.10Arithmetic(n = 71)(n = 37)(n = 25)(n = 9) Mean (SD)7.7 (2.6)8.4 (2.7)6.8 (2.4)7.2 (1.2) Median (quartile range)7.0 (6.0–9.0)8.0 (6.0–9.5)7.0 (5.0–7.5)7.0 (6.5–7.5)0.05Vocabulary(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)6.8 (1.5)7.2 (1.2)6.4 (1.7)6.5 (1.7) Median (quartile range)7.0 (6.0–8.0)7.0 (6.7–8.0)7.0 (5.0–7.7)6.6 (6.0–7.0)0.04Picture Completion(n = 85)(n = 44)(n = 29)(n = 12) Median (SD)7.6 (3.2)7.9 (3.0)7.3 (3.4)6.9 (3.0) Median (quartile range)7.0 (5.0–9.0)8.0 (5.0–10.0)7.0 (5.0–8.5)6.5 (5.2–9.0)0.46Block Design(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)7.1 (2.3)7.3 (2.5)7.0 (2.0)6.9 (2.3) Median (quartile range)7.0 (5.0–8.2)7.0 (5.0–8.2)7.0 (5.0–8.0)6.5 (5.0–9.0)0.57Logical Memory I(n = 88)(n = 45)(n = 31)(n = 12) Mean (SD)16.3 (7.57)17.0 (7.5)15.6 (8.5)15.3 (5.2) Median (quartile range)16.0 (11.0–21.7)16.0 (12.0–23.0)13.0 (10.0–22.0)15.5 (11.2–20.5)0.66Logical Memory II(n = 88)(n = 45)(n = 31)(n = 12) Mean (SD)10.2 (7.9)11.1 (8.3)9.35 (8.15)8.8 (5.0) Median (quartile range)9.0 (4.0–9.0)9.0 (4.0–18.0)7.0 (2.0–15.0)(5.5–8.5)0.51Visual Reproduction I(n = 87)(n = 46)(n = 30)(n = 11) Mean (SD)29.7 (7.5)30.5 (7.3)28.6 (7.8)29.2 (7.8) Median (quartile range)31.0 (24.0–36.0)33.0 (24.0–36.2)29.5 (23.0–36.0)30.0 (27.0–37.0)0.55Visual Reproduction II(n = 87)(n = 46)(n = 30)(n = 11) Mean (SD)19.5 (11.2)20.3 (11.7)19.1 (11.4)17.5 (7.8) Median (quartile range)19.0 (11.0–28.0)20.0 (10.7–29.2)20.0 (10.0–31.0)19.0 (15.0–25.0)0.74RAVLT(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)48.2 (10.6)49.9 (8.6)46.6 (13.8)46.2 (7.0) Median (quartile range)48.5 (43.0–55.0)52.0 (45.0–55.2)46.0 (39.2–58.7)47.0 (44.0–52.7)0.32RAVLT Retention(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)8.9 (3.5)9.37 (3.1)8.5 (3.9)8.1 (3.3) Median (quartile range)9.0 (7.0–12.0)10.0 (7.0–12.0)9.0 (6.0–12.0)8.0 (6.2–10.0)0.38RAVLT (Delayed Recall)(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)8.7 (3.8)9.3 (3.5)8.0 (4.4)7.9 (3.2) Median (quartile range)9.0 (6.0–11.0)10.0 (7.0–11.2)8.0 (5.0–11.0)7.5 (6.0–10.0)0.06RVDLT(n = 83)(n = 42)(n = 30)(n = 11) Mean (SD)25.6 (12.1)28.4 (12.8)23.9 (11.3)19.4 (8.7) Median (quartile range)24.0 (17.0–34.0)28.0 (18.0–37.2)24.0 (16.0–29.5)18.0 (13.0–29.0)0.57RVDLT Retention(n = 82)(n = 41)(n = 29)(n = 12) Mean (SD)6.5 (3.8)6.9 (3.6)6.1 (3.1)5.9 (4.0) Median (quartile range)6.0 (3.7–9.0)7.0 (4.0–10.0)6.0 (3.5–8.5)4.0 (2.0–8.0)0.21RVDLT (Delayed Recall)(n = 84)(n = 42)(n = 30)(n = 12) Mean (SD)5.9 (3.3)6.5 (3.6)5.3 (3.1)5.2 (2.5) Median (quartile range)5.0 (3.0–8.0)6.0 (4.0–8.0)5.0 (2.0–7.2)5.0 (3.2–6.7)0.25Copy of Rey–Osterrieth Figure(n = 87)(n = 44)(n = 31)(n = 12) Mean (SD)29.6 (6.9)30.6 (6.1)29.0 (7.2)27.1 (8.4) Median (quartile range)32.0 (28.0–34.0)33.0 (29.2–35.0)31.00 (27.0–34.0)29.2 (23.6–32.7)0.15aP values were determined by ANOVA.Rey–Osterrieth Figure Recall(n = 86)(n = 44)(n = 30)(n = 12) Mean (SD)10.9 (7.1)12.3 (7.4)9.5 (8.2)9.1 (6.1) Median (quartile range)9.7 (5.9–15.0)12.5 (6.9–16.9)8.2 (4.0–13.5)7.5 (5.6–14.5)0.34Boston Naming Test(n = 90)(n = 46)(n = 32)(n = 12) Mean (SD)40.3 (11.5)42.0 (11.3)38.3 (12.0)39.0 (11.2) Median (quartile range)42.0 (31.7–49.0)44.0 (32.7–50.2)40.0 (29.5–47.0)40.5 (29.2–48.2)0.60a P values were determined by ANOVA. Open table in a new tab Table 2Association between clinical, demographic, neurophysiological, and neuroimaging variables and cognitive performance on the Similarities and Arithmetic testsVariableAll patients (n = 90)Similarities (n = 85)P valueArithmetic (n = 71)P valueSex Male437.3 (2.4)aMean (SD).8.5 (2.7) Female477.0 (2.1)0.557.0 (2.3)0.01Ethnicity European-Brazilians817.2 (2.3)7.7 (2.6) African-Brazilians96.8 (1.8)0.697.5 (2.9)0.87Occupation Unemployed67.2 (2.2)7.7 (2.0) Unskilled labor656.7 (2.0)7.2 (2.3) Semiskilled/professional labor198.8 (2.3)0.0019.0 (3.1)0.05History of IPIbInitial Precipitating Injury. No607.5 (2.4)8.0 (2.9) Yes306.7 (2.0)0.117.2 (1.8)0.23Family history of epilepsy No337.3 (2.3)7.9 (2.6) Yes576.8 (2.2)0.327.0 (2.4)0.22Interictal spikescInterictal spikes were not quantified in three patients. The P values were determined by Student t test or ANOVA. Unilateral617.1 (2.2)7.6 (2.6) Bilateral277.2 (2.4)0.807.8 (2.7)0.78Pharmacotherapy Monotherapy197.6 (2.5)8.5 (3.4) Polytherapy717.1 (2.2)0.397.5 (2.3)0.16Associated benzodiazepines No237.4 (2.4)8.4 (3.1) Yes677.1 (2.2)0.527.5 (2.4)0.19Other drugs No797.2 (2.3)7.7 (2.5) Yes116.9 (1.9)0.677.8 (3.6)0.87Side of seizure onset Right377.9 (2.2)7.7 (1.2) Left536.7 (2.2)0.027.7 (2.5)0.99MRI Unilateral827.2 (2.7)7.6 (2.5) Bilateral87.0 (2.3)0.818.4 (2.8)0.44Handedness Right827.2 (2.2)7.7 (2.5) Nonright87.9 (2.7)0.828.2 (4.1)0.66Surgical outcome Seizure-free777.3 (2.3)7.7 (2.7) Seizure136.4 (1.6)0.167.7 (2.1)0.97a Mean (SD).b Initial Precipitating Injury.c Interictal spikes were not quantified in three patients. The P values were determined by Student t test or ANOVA. Open table in a new tab Table 3Association between clinical, demographic, neurophysiological, and neuroimaging variables and cognitive performance on the Vocabulary and Rey Visual Design Learning TestsVariableAll patients (n = 90)Vocabulary (n = 90)P valueRVDLT (n = 83)P valueSex Male436.7 (1.6)aMean (SD).26.5 (12.8) Female477.0 (1.3)0.3124.7 (11.5)0.52Ethnicity European-Brazilians816.9 (1.3)26.2 (12.0) African-Brazilians96.3 (2.8)0.2818.3 (12.4)0.10Occupation Unemployed65.7 (2.2)20.0 (4.6) Unskilled labor656.6 (1.3)23.6 (11.2) Semiskilled/professional labor198.0 (1.2)<0.00133.1 (13.4)0.006History of IPIbInitial Precipitating Injury. No606.9 (1.1)25.8 (11.3) Yes306.7 (1.2)0.4325.1 (12.6)0.80Family history of epilepsy No337.0 (1.4)26.6 (12.6) Yes576.4 (1.6)0.0822.8 (15.5)0.21Interictal spikescInterictal spikes were not quantified in three patients. The P values were determined by Student t test or ANOVA. Unilateral616.7 (1.5)24.6 (10.9) Bilateral277.1 (1.4)0.2527.7 (13.9)0.29Pharmacotherapy Monotherapy197.3 (2.0)28.5 (16.3) Polytherapy716.7 (1.3)0.1224.7 (10.6)0.24Associated benzodiazepines No237.2 (1.9)26.6 (15.6) Yes676.7 (1.3)0.1725.2 (10.6)0.64Other drugs No796.8 (1.5)26.0 (12.2) Yes116.8 (1.7)0.9522.5 (11.3)0.43Side of seizure onset Right377.2 (1.2)27.4 (13.8) Left536.6 (1.7)0.0524.5 (11.0)0.29MRI Unilateral826.8 (1.5)26.1 (12.2) Bilateral87.1 (1.6)0.5820.4 (10.8)0.25Handedness Right826.9 (1.5)25.9 (12.5) Nonright86.1 (1.7)0.1622.0 (7.5)0.42Surgical outcome Seizure-free776.9 (1.6)26.2 (12.0) Seizure136.6 (1.0)0.5522.1 (13.0)0.31a Mean (SD).b Initial Precipitating Injury.c Interictal spikes were not quantified in three patients. The P values were determined by Student t test or ANOVA. Open table in a new tab As described in the original article, controlling for the effects of interactions of clinical, demographic, electrophysiological, and neuroimaging variables by multiple linear regression analysis (Table 4), we still conclude that 129 SNPs are not associated with cognitive performance in MTLE-HS patients.Table 4Final model of linear logistic regression that better explains differences in the cognitive performance on the Similarities, Arithmetic, Vocabulary, and RVDLT testsVariables (N)Mean squareFP valueSimilarities Education98.526.6<0.001 Age29.27.90.006Arithmetic Education181.244.4<0.001Vocabulary Education70.851.9<0.001 Side of surgery5.94.30.04 Age5.23.70.05RVDLT Education2839.426.3<0.001 Age599.35.50.02 Carbamazepine level409.83.790.05 Open table in a new tab Thus, we deeply apologize for unintentionally permitting partially incorrect data to reach the scientific community. In our article we described the lack of association between cognitive performance of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) and the presence of single-nucleotide polymorphisms (SNPs) at codons 129 and 171 of the cellular prion protein gene (PRNP). Unfortunately, a second researcher in our group was unable to reproduce a portion of these data when reevaluating 90% of the patient samples. The present results indicate that the prevalence of the variant allele N171S is 2.2% (2 cases in 90), which makes statistical analysis of the association between cognitive performance and 171 SNPs impracticable. The association between cognitive performance and codon 129 SNP is presented in Table 1. There was a trend toward lower performance on tests of similarities, arithmetic, vocabulary, and the Rey Visual Design Learning Test (RVDLT) in patients with the variant allele M129V or V129V when compared with those presenting M129M. In Table 2, Table 3, we describe the covariables that could be associated with the performance on these cognitive tests. As described in the original article, controlling for the effects of interactions of clinical, demographic, electrophysiological, and neuroimaging variables by multiple linear regression analysis (Table 4), we still conclude that 129 SNPs are not associated with cognitive performance in MTLE-HS patients. Thus, we deeply apologize for unintentionally permitting partially incorrect data to reach the scientific community. Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171Epilepsy & BehaviorVol. 8Issue 3PreviewCognitive impairment has long been recognized in people with medically refractory epilepsies. Mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS), the most common surgically remediable epileptic syndrome, has been associated with a cellular prion protein (PrPc) gene (Prnp) variant allele at codon 171. The polymorphism consisting of a methionine-for-valine substitution at codon 129 has been associated with early cognitive deterioration in elderly people and patients with Down syndrome. Full-Text PDF
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