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Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery

2011; Elsevier BV; Volume: 152; Issue: 2 Linguagem: Inglês

10.1016/j.jconrel.2011.02.024

1873-4995

Bart Geers, Ine Lentacker, Niek N. Sanders, Joseph Demeester, Stephen Meairs, Stefaan C. De Smedt,

Ultrasound and Cavitation Phenomena

Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues.