Copper-mediated One-pot Synthesis of Trifluorostyrene Derivatives from Tetrafluoroethylene and Arylboronate
2015; Oxford University Press; Volume: 44; Issue: 7 Linguagem: Inglês
10.1246/cl.150322
ISSN1348-0715
AutoresKotaro Kikushima, Hironobu Sakaguchi, Hiroki Saijo, Masato Ohashi, Sensuke Ogoshi,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract We developed the copper-mediated synthesis of trifluorostyrene derivatives. β-Fluorine elimination of a 2-aryl-1,1,2,2-tetrafluoroethylcopper complex, generated in situ from arylboronate, copper tert-butoxide, and 1,10-phenanthroline with tetrafluoroethylene (TFE) via carbocupration, was promoted by the addition of a Lewis acid. The present reaction system was applied to the one-pot synthesis of various trifluorostyrene derivatives, through the transmetalation–carbocupration–β-fluorine elimination sequence.
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