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Increased plasma monocyte chemoattractant protein‐1 level in idiopathic pulmonary arterial hypertension

2006; Wiley; Volume: 11; Issue: 2 Linguagem: Inglês

10.1111/j.1440-1843.2006.00821.x

1440-1843

Takefumi Itoh, Noritoshi Nagaya, Hatsue Ishibashi‐Ueda, Shingo Kyotani, Hideo Oya, Fumio Sakamaki, Hiroshi Kimura, Norifumi Nakanishi,

Protease and Inhibitor Mechanisms

Objective: Monocyte chemoattractant protein‐1 (MCP‐1), a pro‐inflammatory chemokine, has potent chemoattractant activity for monocytes/macrophages. We sought to investigate the clinical significance of MCP‐1 in idiopathic pulmonary arterial hypertension (IPAH). Methods: This study included 28 patients with IPAH, seven patients with pulmonary arterial hypertension (PAH) related to collagen vascular disease, and 13 healthy subjects. Plasma MCP‐1 levels were measured together with serum IL‐6 and tumour necrosis factor‐α (ΤΝF‐α) levels. Results: Circulating levels of MCP‐1, IL‐6 and ΤΝF‐α were significantly higher in patients with IPAH than in healthy controls, although they were lower than in patients with PAH related to collagen vascular disease. Plasma MCP‐1 did not significantly correlate with any haemodynamic variables. However, plasma MCP‐1 levels correlated negatively with the disease duration (time from symptom onset). Conclusions: Plasma MCP‐1 levels were elevated in patients with IPAH, and this elevation was particularly marked in the early stage of disease. Taking into account the chemoattractant activity of MCP‐1, these results imply a contribution of MCP‐1 to the development of pulmonary hypertension.