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Hypersensitivity pneumonitis with antibodies to Cryptococcus neoformans

1978; Wiley; Volume: 8; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2222.1978.tb01503.x

1365-2222

Toshi Miyagawa, Tadao Ochi, H. TAKAHASHI,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Summary Clinical and immunological studies were made in forty‐two patients diagnosed as suffering from hypersensitivity pneumonitis at Osaka Prefectural Habikino Hospital between 1973 and 1977. All the sera from forty‐one patients tested had high litres of antibody against Cryptococcus neoformans in indirect fluorescent antibody tests, and twelve also had precipitins against Cryptococcus neoformans polysaccharide. Only about 10% of control sera from patients with otherlung diseases had low titresof antibody against Cryptococcus neoformans . Antibody against Cryptococcus neoformans was also found frequently in the sera of asymptomatic members of the families of the patients. A possible relationship of Cryptococcus neoformans to hypersensitivity pneumonitis is suggested.