Lewis Base Activation of Lewis Acids. Catalytic Enantioselective Addition of Silyl Enol Ethers of Achiral Methyl Ketones to Aldehydes
2003; American Chemical Society; Volume: 5; Issue: 13 Linguagem: Inglês
10.1021/ol034641l
ISSN1523-7060
AutoresScott E. Denmark, John R. Heemstra,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA highly enantioselective addition of silyl enol ethers derived from simple methyl ketones is described. The catalyst system of silicon tetrachloride activated by a chiral bisphosphoramide (R,R)-7 effectively promotes the addition of a variety of unsubstituted silyl enol ethers to aromatic, olefinic, and heteroaromatic aldehydes in excellent yield. [reaction: see text]
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