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Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance

2008; Baishideng Publishing Group; Volume: 14; Issue: 41 Linguagem: Inglês

10.3748/wjg.14.6376

2219-2840

Kamran Ghaffarzadehgan, Mostafa Jafarzadeh, Hamid Raziee, Hamid Reza Sima, Ehsan Esmaili Shandiz, Hanieh Hosseinnezhad, Ali Taghizadeh-Kermani, Omeed Moaven, Maryam Bahrani,

Genetic factors in colorectal cancer

used for histological evaluation, including the type (Lauren's classification) and grading of the tumor.The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry.The survival analysis was obtained using the Kaplan-Meier test.RESULTS: Of 100 patients, 74 (74%) patients were male.The tumors were categorized as intestinal type (78%) or diffuse type (22%).Sixty-five percent of patients were CD44-positive.CD44 expression was not detected in normal gastric mucosa.Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002).A significant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014).The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type.CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma.CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma.CD44 can, therefore, be utilized as a prognostic marker for this group of patients.