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SOMATOSTATIN AND WATER EXCRETION IN MAN: AN INTRARENAL ACTION

1985; Wiley; Volume: 23; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2265.1985.tb00212.x

1365-2265

BeverleyJ. Walker, P Evans, Mary L. Forsling, G.A. Nelstrop,

Chemical and Physical Studies

SUMMARY Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.