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Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats

1998; Lippincott Williams & Wilkins; Volume: 9; Issue: 6 Linguagem: Inglês

10.1097/00001756-199804200-00038

1473-558X

Kim Fisher, Terence J. Coderre,

Eicosanoids and Hypertension Pharmacology

To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5 agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48°C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR1/5 receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury.