Cell-Free Biosynthesis of Fluoroacetate and 4-Fluorothreonine in Streptomyces cattleya
2002; Wiley; Volume: 41; Issue: 20 Linguagem: Inglês
10.1002/1521-3773(20021018)41
ISSN1521-3773
AutoresChristoph Schaffrath, Steven L. Cobb, David O′Hagan,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoThe biosynthesis of organofluorine compounds, for example, fluoroacetate, was demonstrated from (S)-adenosyl-L-methionine (SAM) and fluoride ions in a cell-free extract of Streptomyces cattleya. Incubation of 5′-fluoro-5′-deoxyadenosine (5′-FDA), the first organofluorine product formed in the fluoroacetate pathway, with the cell-free extract resulted in the transient accumulation of fluoroacetaldehyde, thus confirming its role as an intermediate in the synthesis of fluorometabolites (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z19887_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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