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Role of adrenergic pathways of the medial preoptic area in ANGII-induced water intake and renal excretion in rats

1994; Elsevier BV; Volume: 636; Issue: 1 Linguagem: Inglês

10.1016/0006-8993(94)90178-3

1872-6240

Rosemary Bastos, Wilson A. Saad, José Vanderlei Menani, Antonio Renzi, JoséEduardo Nogueira Silveira, Luiz Antônio de Arruda Camargo,

Hormonal Regulation and Hypertension

In this study, we investigated the participation of adrenergic neurotransmission in angiotensin II- (ANGII)-induced water intake and urinary electrolyte excretion by means of injection of the α1-, α2-, and β-adrenoceptor antagonists and ANGII into the medial preoptic area (MPOA) in rats. Prazosin (an α1-adrenergic antagonist) entagonized the water ingestion, Na+, K+ and urine excretion induced by ANGII, whereas yohimbine (an α2-adrenergic antagonist) enhanced the Na+, K+ and urine excretion induced by ANGII. Propranolol (a nonselective β-adrenoceptor blocker) antagonized the water ingestion and enhanced the Na+, and urine excretion induced by ANGII. Previous treatment with prazosin reduced the pressor responses to ANGII, whereas yohimbine had opposite effects. Previous injection of propranolol produced no effects in the pressor responses to ANGII. These results suggest that the adrenergic neurotransmission in the MPOA may actively participate in ANGII-induced dipsogenesis, natriuresis, kaliuresis and diuresis in a process that involves α1-, α2-,andβ-adrenoceptors.