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Effects of Two Saponins Extracted from the Polygonatum Zanlanscianense Pamp on the Human Leukemia (HL-60) Cells.

2001; Pharmaceutical Society of Japan; Volume: 24; Issue: 2 Linguagem: Inglês

10.1248/bpb.24.159

1347-5215

Zhao Wang, Jiangbing Zhou, Yong Ju, Hongjun Zhang, Mingjie Liu, Xue Li,

Natural product bioactivities and synthesis

Two saponins, methyl protodioscin and dioscin, were extracted from the root of Polygonatum Zanlanscianense Pamp. One of them, dioscin exerted significant inhibitory effects on the growth of the human leukemia cell HL-60, inducing differentiation and apoptosis. HL60 cells were induced mainly along the granulocytic lineage. In addition, we have found that dioscin affects many cancer cells. These studies may have important significance in treating related cancers.