Identification of the major urinary metabolite of alprenolol in man, dog and rat
1974; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/0024-3205(74)90451-2
ISSN1879-0631
Autores Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoAfter oral administration of 3H-alprenolol to man, dog and rat, urinary metabolites of the drug have been separated by ion-exchange chromatography on Bio-Rex 70, a carboxylic acrylate resin. The major metabolite has been identified by GC-MS as 4-hydroxyalprenolol. Occurring in the urine largely in a conjugated form, it represents about 40 % of the excreted amount in man and dog and about 30 % in rat. Including alprenolol, which also appears largely as a conjugate, about 80 % of the amount of radioactivity excreted in human urine can be accounted for.
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