FISH in genome research and molecular diagnostics
1995; Elsevier BV; Volume: 5; Issue: 3 Linguagem: Inglês
10.1016/0959-437x(95)80043-3
ISSN1879-0380
AutoresGert‐Jan B. van Ommen, Martijn H. Breuning, Anton K. Raap,
Tópico(s)Congenital heart defects research
ResumoFluorescence in situ hybridization (FISH) has profoundly altered the aspect of genome research and molecular diagnostics. Deletions of only a few kilobases can be detected by hybridizing probes to naked DNA fibers. Loss or gain of chromosomal material in tumor cells can be visualized using comparative genome hybridization. Further diversification of FISH application will result from new ultrasensitive detection techniques.
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