Portal de Periódicos da CAPES

Central Physeal Arrests as a Manifestation of Hypervitaminosis A

2007; Lippincott Williams & Wilkins; Volume: 27; Issue: 3 Linguagem: Inglês

10.1097/bpo.0b013e3180340a06

1539-2570

Matthew R. Saltzman, Erik C. King,

Vitamin K Research Studies

Vitamin A is necessary for synthesis of visual pigments and required in appropriate amounts for membrane stability. Acute hypervitamin A intoxication can lead to increased intracranial pressure, vomiting, and lethargy. Chronic excessive intake of vitamin A can lead to pruritis, muscle and bone tenderness, and failure to thrive. Reported effects of hypervitamin A intoxication on bone include osteoporosis, fracture, cortical thickening, and metaphyseal irregularity. We are reporting on a case of central physeal arrest in the distal femur, proximal tibia, and distal tibia after excessive intake of vitamin A.