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Synthesis of penaresidin derivatives and its biological activity

2007; Elsevier BV; Volume: 15; Issue: 14 Linguagem: Inglês

10.1016/j.bmc.2007.04.049

1464-3391

Kengo Ohshita, Haruaki Ishiyama, Yohei Takahashi, Junji Ito, Yuzuru Mikami, Jun’ichi Kobayashi,

Synthetic Organic Chemistry Methods

A series of stereoisomers for the azetidine ring of penaresidin B was synthesized and their cytotoxic and antimicrobial activities were evaluated. Among six synthetic isomers 1–6, isomers 4 and 5 showed relatively potent cytotoxic activity against A549 (lung) and HT29 (colon) tumor cells as well as antibacterial activity.