Preparation and inverse electron demand Diels-Alder reactions of 3-methoxy-6-methylthio-1,2,4,5-tetrazine
1997; Elsevier BV; Volume: 38; Issue: 22 Linguagem: Inglês
10.1016/s0040-4039(97)00751-x
ISSN1873-3581
AutoresSubas M. Sakya, Kelley K. Groskopf, Dale L. Boger,
Tópico(s)Synthesis and Biological Evaluation
ResumoThe selective preparation of 3-methoxy-6-methylthio-1,2,4,5-tetrazine (2) and 3,6-dimethoxy-1,2,4,5-tetrazine (3) from 3,6-bis(methylthio)-1,2,4,5-tetrazine (1) is described. A preliminary investigation into the participation of 2 in [4+2] cycloaddition reactions with electron rich and neutral dienophiles along with the resulting regioselective formation of the products (5) are discussed.
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