N-Alkyl cysteine-assisted thioesterification of peptides
2006; Elsevier BV; Volume: 48; Issue: 1 Linguagem: Inglês
10.1016/j.tetlet.2006.11.034
ISSN1873-3581
AutoresHironobu Hojo, Yuko Onuma, Yuri Akimoto, Yuko Nakahara, Yoshiaki Nakahara,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoA new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc SPPS. The synthetic peptides released from resin by TFA were readily converted to the peptide thioester in aqueous 3-mercaptopropionic acid (MPA) without significant side reactions.
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