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The expression of suppressor of cytokine signaling 1 and 3 in fat and placental tissue from women with gestational diabetes

2012; Informa; Volume: 28; Issue: 11 Linguagem: Inglês

10.3109/09513590.2012.683055

1473-0766

Mariusz Kuźmicki, Beata Telejko, Natalia Wawrusiewicz‐Kurylonek, Anna Citko, Danuta Lipińska, Justyna Pliszka, Juliusz Wilk, Katarzyna Kalejta, Adam Lemancewicz, Marek Grabiec, Anna M. Pryszczepko-Wawreszuk, Justyna Skibicka, Adam Krętowski, Maria Górska, Jacek Szamatowicz,

Apelin-related biomedical research

The suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of signaling pathways induced by cytokines, hormones and growth factors. In the present study we measured the expression of SOCS1, SOCS3, interleukin-6 (IL-6), IL-6 receptor, IL-8 and leptin mRNA in paired samples of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placental tissue obtained from 18 pregnant women with normal glucose tolerance (NGT) and 20 subjects with gestational diabetes mellitus (GDM), using quantitative RT-PCR. The patients with GDM had significantly higher IL-8 mRNA expression in VAT than the women with NGT (p = 0.007), whereas the expression of SOCS1, SOCS3 and other genes study did not differ significantly between the two groups. Stepwise regression analysis revealed that SOCS1 mRNA expression in VAT was significantly associated with prepregnancy BMI (β = −0.68, p = 0.03) and IL-8 mRNA expression (β = 0.66, p = 0.03), whereas SOCS3 mRNA expression in VAT was independently predicted by IL-6 mRNA expression (β = 0.94, p = 0.0002, R2 = 0.88). In conclusion, our results did not show significant differences in SOCS1 and SOCS3 mRNA expression in adipose and placental tissue obtained from pregnant women with and without GDM.