Portal de Periódicos da CAPES

Heteroarylisopropylamines as MAO inhibitors

2005; Elsevier BV; Volume: 13; Issue: 14 Linguagem: Inglês

10.1016/j.bmc.2005.04.045

1464-3391

Gabriel Vallejos, Angélica Fierro, Marcos Caroli Rezende, Silvia Sepúlveda‐Boza, Miguel Reyes‐Parada,

Neurotransmitter Receptor Influence on Behavior

The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.