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TNF‐α‐Converting Enzyme Activity in Colonic Biopsy Specimens from Patients with Inflammatory Bowel Disease Revealed by mRNA and in Vitro Assay

1999; Wiley; Volume: 878; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1999.tb07764.x

1749-6632

PIA FØGH, Christina Ellervik, Torben Særmark, Jørn Brynskov,

Celiac Disease Research and Management

Annals of the New York Academy of SciencesVolume 878, Issue 1 p. 692-695 TNF-α-Converting Enzyme Activity in Colonic Biopsy Specimens from Patients with Inflammatory Bowel Disease Revealed by mRNA and in Vitro Assay PIA FØGH, PIA FØGH Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorCHRISTINA ELLERVIK, CHRISTINA ELLERVIK Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorTORBEN SÆRMARK, TORBEN SÆRMARK Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorJØRN BRYNSKOV, Corresponding Author JØRN BRYNSKOV Corresponding author: Dr. J. Brynskov, M.D., D.M.Sc. Phone, +45 4488 3625; fax, +45 4494 4056; e-mail, [email protected]Search for more papers by this author PIA FØGH, PIA FØGH Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorCHRISTINA ELLERVIK, CHRISTINA ELLERVIK Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorTORBEN SÆRMARK, TORBEN SÆRMARK Department of Gastroenterology C, Herlev University Hospital, DK-2730 Herlev, Copenhagen, DenmarkSearch for more papers by this authorJØRN BRYNSKOV, Corresponding Author JØRN BRYNSKOV Corresponding author: Dr. J. Brynskov, M.D., D.M.Sc. Phone, +45 4488 3625; fax, +45 4494 4056; e-mail, [email protected]Search for more papers by this author First published: 06 February 2006 https://doi.org/10.1111/j.1749-6632.1999.tb07764.xCitations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1 Targan, S.R. et al. 1997. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor a for Crohn's disease. N. Engl. J. Med. 337: 1029– 1035. 2 Evans, R.C. et al. 1997. Treatment of ulcerative colitis with an engineered human anti-TNF-α antibody CDP571. Aliment Pharmacol. Ther. 11: 1031– 1035. 3 Black, R.A. et al. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor-a from cells. Nature 385: 729– 732. 4 Moss, M.L. et al. 1997. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α. Nature 385: 733– 736. 5 Maskos, K. et al. 1998. Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme. Proc. Natl. Acad. Sci. USA 95: 3408– 3412. 6 Patel, I.R. et al. 1998. TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-α. J. Immunol. 160: 4570– 4579. 7 Munkholm, P. et al. 1992. Incidence and prevalence of Crohn's disease in the county of Copenhagen, 1962-87: a sixfold increase in incidence. Scand. J. Gastroenterol. 27: 609– 614. 8 Langholtz et al. 1994. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology 107: 3– 11. 9 Mohler, K.M. et al. 1994. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370: 218– 220. 10 Black, R.A. et al. 1996. Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-α (TNF-α) production suggest the major TNF-α converting enzyme is not an MMP. Biochem. Biophys. Res. Commun. 225: 400– 405. Citing Literature Volume878, Issue1INHIBITION OF MATRIX METALLOPROTEINASES THERAPEUTIC APPLICATIONSJune 1999Pages 692-695 ReferencesRelatedInformation