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Screening for Aetiology of Thrombophilia: A High Prevalence of Protein S Abnormality

1999; SAGE Publishing; Volume: 36; Issue: 4 Linguagem: Inglês

10.1177/000456329903600404

1758-1001

Hiroko Tsuda, Sachiko Hattori, Sohei Tanabe, Hiroko Iida, Mutsuko Nakahara, Satoshi Nishioka, Masako Fujise, Sachiko Kinoshita, Kumiko Okubo, Naotaka Hamasaki,

Protease and Inhibitor Mechanisms

We systematically screened for the aetiology of thrombophilia in 115 patients with venous, arterial and small vessel thromboses. Forty-one patients (36% of those we examined) suffering from a variety of thromboses, including deep vein thrombosis, pulmonary embolism, arterial occlusion, cerebral infarction, Moyamoya disease and ulcerative colitis, were characterized either with positive lupus anticoagulants or with decreased activities of protein S, protein C, antithrombin III and/or plasminogen. Eight mutation sites were confirmed in 11 thrombotic patients using gene analysis. Decreased protein S activity was found with a high incidence (23 out of 115) in Japanese patients who suffered from not only venous thrombosis but also arterial and small vessel thrombosis. We emphasize here the important role of protein S in the pathogenesis of thrombosis in the Japanese population.