Portal de Periódicos da CAPES

Comparative theoretical study of the conformations of amphotericin methyl ester and amphotericin B polar heads in the presence of water

1992; Elsevier BV; Volume: 1112; Issue: 2 Linguagem: Inglês

10.1016/0005-2736(92)90401-7

1879-2642

Sonja Meddeb, Jacqueline Bergès, J. Caillet, J. Langlet,

Analytical Chemistry and Chromatography

Amphotericin methyl ester (AmE) is an interesting derivative of amphotericin B (AmB) because of its enhancement of selectivity against the fungicells. Both AmB and AmE molecules differ by the structure of their polar heads. This work deals with a theoretical study of conformations of the polar head of AmE in the presence of hydration water molecules. The results will be compared with our previous work concerning AmB.