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Candida albicans pathogenicity: A proteomic perspective

1999; Wiley; Volume: 20; Issue: 11 Linguagem: Inglês

10.1002/(sici)1522-2683(19990801)20

1522-2683

Masakazu Niimi, Richard D. Cannon, Brian C. Monk,

Probiotics and Fermented Foods

ELECTROPHORESISVolume 20, Issue 11 p. 2299-2308 Review Candida albicans pathogenicity: A proteomic perspective Masakazu Niimi, Corresponding Author masa.niimi@stonebow.otago.ac.nz Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandMolecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand, Fax: +64-3-479-0673===Search for more papers by this authorRichard D. Cannon, Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandSearch for more papers by this authorBrian C. Monk, Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandSearch for more papers by this author Masakazu Niimi, Corresponding Author masa.niimi@stonebow.otago.ac.nz Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandMolecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand, Fax: +64-3-479-0673===Search for more papers by this authorRichard D. Cannon, Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandSearch for more papers by this authorBrian C. Monk, Molecular Microbiology Laboratory, Department of Oral Sciences and Orthodontics, School of Dentistry, University of Otago, Dunedin, New ZealandSearch for more papers by this author First published: 18 August 1999 https://doi.org/10.1002/(SICI)1522-2683(19990801)20:11 3.0.CO;2-7Citations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Candida albicans is an opportunistic fungus which causes both superficial infections and life-threatening systemic candidiasis in immunocompromised hosts such as AIDS patients, people with cancer, or other immunosuppressed individuals. Virulence factors for this fungus include the ability to adhere to host tissues, production of tissue damaging secreted enzymes, and changes in morphological form that may enhance tissue penetration and avoidance of immune surveillance. Treatment of candidiasis patients is hampered by a limited choice of antifungal agents and the appearance of clinical isolates resistant to azole drugs. Proteome analysis involves the separation and isolation of proteins by two-dimensional gel electrophoresis and their identification and characterization by mass spectrometry. The systematic application of this methodology to C. albicans is in its infancy, but is progressing rapidly. Comparing protein profiles between avirulent and virulent C. albicans strains, between drug-sensitive and -resistant strains, or between different morphological forms, could identify key control and effector proteins. There are difficulties, however, associated with the display of low abundance and cell envelope-associated proteins and the choice of conditions for obtaining suitable C. albicans cells. This article describes the potential of applying proteome analysis to C. albicans in order to better understand pathogenicity and identify new antifungal targets. Citing Literature Volume20, Issue111 August 1999Pages 2299-2308 RelatedInformation