Revisão Acesso aberto Revisado por pares

The heme oxygenase-carbon monoxide system: u regulator of hepatobiliary function

2000; Lippincott Williams & Wilkins; Volume: 31; Issue: 1 Linguagem: Inglês

10.1002/hep.510310102

ISSN

1527-3350

Autores

Makoto Suematsu, Yuzuru Ishimura,

Tópico(s)

Cannabis and Cannabinoid Research

Resumo

HepatologyVolume 31, Issue 1 p. 3-6 Concise ReviewFree Access The heme oxygenase–carbon monoxide system: u regulator of hepatobiliary function Makoto Suematsu M.D., Ph.D.,, Corresponding Author Makoto Suematsu M.D., Ph.D., [email protected] From the Department of Biochemistry, School of Medicine, Keio University, Tokyo, JapanDepartment of Biochemistry, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan===Search for more papers by this authorYuzuru Ishimura, Yuzuru Ishimura From the Department of Biochemistry, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this author Makoto Suematsu M.D., Ph.D.,, Corresponding Author Makoto Suematsu M.D., Ph.D., [email protected] From the Department of Biochemistry, School of Medicine, Keio University, Tokyo, JapanDepartment of Biochemistry, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan===Search for more papers by this authorYuzuru Ishimura, Yuzuru Ishimura From the Department of Biochemistry, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510310102Citations: 105AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by nicrosomal heme oxygenase. Proc Natl Acad Sci U S A 1968; 61: 748–755.MEDLINE 2 Maines MD, Kappas A. Cobalt induction of hepatic heme oxygenase: with evidence that cytochrome P450 is not essential for this enzyme activity. Proc Natl Acad Sci U S A 1974; 71: 4293–4297.MEDLINE 3 Yoshida T, Kikuchi G. Partial purification and reconstruction of the heme oxygenase system from pig spleen microsomes. Biochem J 1974; 75: 1187–1191. 4 Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 1988; 2: 2557–2568.MEDLINE 5 Kutty RK, Daniel RF, Ryan DE, Levin W, Maines MD. Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliveridin by heme oxygenase. Arch Biochem Biophys 1988; 260: 638–644.MEDLINE 6 Shibahara S, Muller R, Taguchi H, Yoshida T. Cloning and expression of cDNA of rat heme oxygenase. Proc Natl Acad Sci U S A 1985; 82: 7865–7869.MEDLINE 7 Maines MD, Trakshel GM, Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase: only one molecular species of the enzyme is inducible. J Biol Chem 1986; 261: 411–419.MEDLINE 8 McCoubrey Jr WK, Huang TJ, Maines MD. Isolation of characterization of cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 1997; 247: 725–732.MEDLINE 9 Tacchini L, Schiaffonati L, Pappalardo C, Gatti C, Bernelli-Zazzera A. Expression of HSP 70, immediate-early response and heme oxygenase genes in ischemia-reperfused rat liver. Lab Invest 1993; 68: 465–471.MEDLINE 10 Choi AMK, Alam J. Heme oxygenase-1: function, regulation and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996; 15: 9–19.MEDLINE 11 Rizzardini M, Carelli M, Cabello-Porras MR, Cantoni L. Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine. Biochem J 1994; 304: 477–483.MEDLINE 12 Schoendorf TH, Rosenberg M, Beller FK. Endotoxin-induced disseminated intravascular coagulation in nonpregnant rats. A new experimental model. Am J Pathol 1971; 65: 51–58.MEDLINE 13 Nath KA, Balla G, Vercellotti GM, Balla J, Jacob HS, Levitt MD, Rosenberg ME. Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest 1992; 90: 267–270.MEDLINE 14 Immenschuh S, Hinke V, Ohlmann A, Gifhorn-Katz S, Katz N, Jungermann K, Kietzmann T. Transcriptional activation of the haem oxygenase-1 gene by cGMP via cAMP response element /activator protein-1 element in primary cultures of rat hepatocytes. Biochem J 1998; 334: 141–146.MEDLINE 15 Maines MD. The heme oxygenase system: a regulator of second messenger gases. Ann Rev Toxicol 1997; 37: 517–554. 16 Jelinek DF, Anderson S, Slaughter CA, Russel DW. Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem 1990; 265: 8190–8197.MEDLINE 17 Estabrook RW, Franklin M, Baron J, Shigematsu A, Hildbrandt A. Properties of the membrane-bound electron transfer complex of the hepatic endoplasmic reticulum associated with drug metabolism. In E Mihich, ed. Drugs and Cell Regulation. New York: Academic Press. 1971; 227–254. 18 Glabe A, Chung Y, Xu D, Jue T. Carbon monoxide inhibition of regulatory pathways in myocardium. Am J Physiol 1998; 274: H2143–H2151.MEDLINE 19 Bissell DM, Hammaker L, Schmid R. Hemoglobin and erythrocyte catabolism in rat liver: the separate roles of parenchymal and sinusoidal cells. Blood 1972; 40: 812–822.MEDLINE 20 Bissell DM, Hammaker LE. Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity. Arch Biochem Biophys 1976; 176: 91–102.MEDLINE 21 Goda N, Suzuki K, Naito M, Takeoka S, Tsuchida E, Ishimura Y, Tamatani T, et al. Distribution of heme oxygenase isoforms in rat liver: topographic basis for carbon monoxide-mediated microvascular relaxation. J Clin Invest 1998; 101: 604–612.MEDLINE 22 Bauer I, Wanner GA, Rensing H, Alte C, Miescher EA, Wolf B, Pannen BH, et al. Expression pattern of heme oxygenase isoenzyme 1 and 2 in normal and stress-exposed rat liver. Hepatology 1998; 27: 829–838.MEDLINE 23 Suematsu M, Kashiwagi S, Sano T, Goda N, Shinoda Y, Ishimura Y. Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem Biophys Res Commun 1994; 205: 1333–1337.MEDLINE 24 Suematsu M, Goda N, Sano T, Kashiwagi S, Shinoda Y, Ishimura Y. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest 1995; 96: 2431–2437.MEDLINE 25 Kawada N, T-A Tran-Thi, Klein H, Decker K. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances: possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem 1993; 213: 815–823.MEDLINE 26 Rockey DC, Chung JJ. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J Clin Invest 1995; 95: 1199–1206.MEDLINE 27 Suematsu M, Oda M, Suzuki H, Kaneko H, Watanabe N, Furusho T, Masushige S, et al. Intravital and electron microscopic observation of Ito cells in rat hepatic microcirculation. Microvasc Res 1993; 46: 28–42.MEDLINE 28 Bauer M, Zhang JX, Bauer I, Clemens MG. Endothelin-1–induced alteration of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am J Physiol 1994; 267: G143–G149.MEDLINE 29 Zhang JX, Pegoli Jr W, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266: G624–G632.MEDLINE 30 Shinoda Y, Suematsu M, Wakabayashi Y, Goda N, Suzuki T, Saito S, Yamaguchi T, et al. Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes. Hepatology 1998; 28: 286–295.MEDLINE 31 Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997; 100: 2923–2930.MEDLINE 32 Bautista AP, Spitzer JJ. Inhibition of nitric oxide formation in vivo enhances superoxide release by the perfused liver. Am J Physiol 1994; 266: G783–G788.MEDLINE 33 Suematsu M, Wakabayashi Y, Ishimura Y. Gaseous monoxides: a new class of microvascular regulator in the liver. Cardiovasc Res 1996; 32: 679–686.MEDLINE 34 Bauer M, Pannen BHJ, Bauer I, Herzog C, Wanner GA, Hanselmann R, Zhang JX, et al. Evidence for a functional link between stress response and vascular control in hepatic portal circulation. Am J Physiol 1996; 271: G929–G935.MEDLINE 35 Pannen BHJ, Koeler N, Hole B, Bauer M, Clemens MG, Geiger KK. Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats. J Clin Invest 1998; 102: 1220–1228.MEDLINE 36 Wakabayashi Y, Takamiya R, Mizuki A, Kyokane T, Goda N, Yamaguchi T, Takeoka S, et al. Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver. Am J Physiol 1999; 277: G1088–G1096.MEDLINE 37 Fernandez M, Bonkovsky HL. Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats. Hepatology 1999; 29: 1672–1679.MEDLINE 38 Poss KD, Tonegawa S. Heme oxygenase-1 is required for mammarian iron reutilization. Proc Natl Acad Sci U S A. 1997; 94: 10919–10924.MEDLINE 39 Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, et al. Oxidative stress causes enhanced vascular endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999; 103: 129–135.MEDLINE 40 Abraham NG, Lavrosky Y, Schwartzman ML, Stoltz RA, Levere RD, Gerritsen ME, Shibahara S, et al. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A 1995; 92: 6798–6802.MEDLINE 41 Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, et al. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 1999; 85: 663–671.MEDLINE 42 Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci U S A 1987; 84: 5918–5922.MEDLINE 43 Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH. Carbon monoxide: a putative neural messenger. Science 1993; 259: 381–384.MEDLINE 44 Brune B, Ullrich V. Inhibition of platelet aggregation by carbon monoxide mediated by activation of guanylate cyclase. Mol Pharmacol 1987; 32: 497–504.MEDLINE 45 Sano T, Shiomi M, Wakabayashi Y, Shinoda Y, Goda N, Yamaguchi T, Nimura Y, et al. Endogenous carbon monoxide suppression stimulates bile acid-dependent biliary transport in perfused rat liver. Am J Physiol 1997; 272: G1268–G1275.MEDLINE 46 Kharitonov VG, Sharma VS, Pilz RB, Magde D, Koesling D. Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci U S A 1995; 92: 2568–2571.MEDLINE 47 Stone JR, Marletta MA. Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 1994; 33: 5636–5640.MEDLINE 48 Stone JR, Marletta MA. Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide. Biochemistry 1996; 35: 1093–1099.MEDLINE 49 Friebe A, Schultz G, Koesling D. Sensitizing soluble guanylate cyclase to become a highly CO-sensitive enzyme. EMBO J 1996; 15: 6863–6868.MEDLINE 50 Oshio C, Phillips MJ. Contractility of bile canaliculi: implications of liver function. Science 1981; 212: 1041–1042.MEDLINE 51 Dufour J.-FJ, Turner TJ, Arias IR. Nitric oxide blocks bile canalicular contraction by inhibiting inositol triphosphate-dependent calcium mobilization. Gastroenterology 1995; 108: 841–849.MEDLINE 52 Fitzpatrick FA, Murphy RC. Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids. Pharmacol Rev 1989; 40: 229–241. 53 Wang WH, Lu M, Hebert SC. Cytochrome P450 metabolites mediate extracellular Ca2+-induced inhibition of apical K+ channels in the TAL. Am J Physiol 1996; 271: C103–C111.MEDLINE 54 Liu H, Mount DB, Nasjletti A, Wang W. Carbon monoxide stimulates the apical 70-pS K+ channel of the rat thick ascending limb. J Clin Invest 1999; 103: 963–970.MEDLINE 55 Mori M, Suematsu M, Kyokane T, Sano T, Suzuki H, Yamaguchi T, Ishimura Y, et al. Carbon monoxide-mediated alterations in paracellular permeability and vesicular transport in acetaminophen-treated perfused rat liver. Hepatology 1999; 30: 160–168.MEDLINE 56 Ortiz de Montellano PR, Correia MA. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism. Ann Rev Toxicol 1983; 23: 481–503. Citing Literature Volume31, Issue1January 2000Pages 3-6 ReferencesRelatedInformation

Referência(s)
Altmetric
PlumX