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Expression of E‐Cadherin in Skin Carcinomas

1996; Wiley; Volume: 23; Issue: 2 Linguagem: Inglês

10.1111/j.1346-8138.1996.tb03979.x

1346-8138

Hideyuki Tada, Mitsuo Hatoko, Tsutomu Muramatsu, Toshihiko Shirai,

Cancer and Skin Lesions

Abstract In this study, we investigated the expression of E‐cadherin in 31 cases of human skin carcinoma including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Paget's disease, Bowen's disease (invasive type), and trichilemmal carcinoma, by immunohistochemical staining using a monoclonal antibody specific for E‐cadherin. Similar to the E‐cadherin expression in normal epidermis, E‐cadherin was strongly expressed in all samples of BCC on the cell borders, whereas marked decrease or loss of E‐cadherin expression was found in the tumor cells of SCC, Paget's disease, and Bowen's disease (invasive type). On the other hand, E‐cadherin expression of trichilemmal carcinoma was slightly reduced. Considering the clinical and histological features of these skin carcinoma, the reduction of E‐cadherin expression is considered to be associated with the invasion and metastasis of human skin carcinoma.