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ADRENAL STRUCTURE AND FUNCTION WITH SPECIAL REFERENCE TO THE RELATIONSHIP BETWEEN THE ZONA GLOMERULOSA AND THE ZONA FASCICULATA

1957; Japan Endocrine Society; Volume: 4; Issue: 1 Linguagem: Inglês

10.1507/endocrj1954.4.35

2185-6370

TAKUJI ANDO,

Nitric Oxide and Endothelin Effects

1. The zona glomerulosa shows a close relationship with calcium and magnesium metabolism in addition to sodium and potassium metabolism. It was observed that the outer and inner cortical layers have a different function.2. An apparent transition was observed between the capsule and the zona glomerulosa in the hypertrophied glomerulosa in the hypertrophied glomerulosa of mice and rats. These findings show that cortical cells originate from capsular cells.3. The glomerulosa structure is capable of alteration to the fasciculata structure, and close continuity was observed in the glomerulosa of rats. This suggests that the cells of the glomerulosa are capable of being transformed into cells of the fasciculata.4. Atrophy of the inner cortical layei s was observed accompanied by hypertrophy of the zona glomerulosa. This finding suggests that the glomerulosa cell and the fasciculata cell have the same origin, and are not independent.5. The results of this experiment shcw that the adrenocortical cells all proliferate from the same origin, and the secretory functions of the outer and inner layers are different. That is, immature glomerulosa cells secrete a hormone which regulates electrolyte metabolism without pituitary control, but transformed mature fasciculata cells stimulated by pituitary ACTH, come to secrete a hormone which regulates sugar metabolism under pituitary control.