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Artigo Revisado por pares
BIBTEX RIS

Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides

2012; Elsevier BV; Volume: 20; Issue: 13 Linguagem: Inglês

10.1016/j.bmc.2012.05.009

ISSN

1464-3391

Autores

S. M. Abdur Rahman, Takeshi Baba, Tetsuya Kodama, Md Ariful Islam, Satoshi Obika,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

Various stereochemically pure cationic phosphorothioate oligonucleotides bearing aminoalkyl moieties were synthesized, and their duplex-forming ability against single-stranded DNA (ssDNA), single-stranded RNA (ssRNA) and triplex-forming ability against double-stranded DNA (dsDNA) were evaluated by UV melting experiments. The cationic Rp stereoisomers showed improved duplex-forming ability against ssDNA, triplex-forming ability against dsDNA and nuclease stability.

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