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Development of a novel fluorapatite-forming calcium phosphate cement with calcium silicate: <i>In vitro</i> and <i>in vivo</i> characteristics

2015; Japanese Society for Dental Materials and Devices; Volume: 34; Issue: 2 Linguagem: Inglês

10.4012/dmj.2014-255

1881-1361

Yusuke Suzuki, Makoto Hayashi, Takuya Yasukawa, Hiroshi Kobayashi, K. Makino, Yoriyuki Hirano, S. Takagi, L.C. Chow, Bunnai Ogiso,

Dental materials and restorations

Aim of this study was to develop a novel fluorapatite-forming calcium phosphate cement (FA-CPC) with tricalcium silicate (TCS) for endodontic applications and to examine its in vitro and in vivo characteristics. The FA-CPC powder consisted of 62.8% CaHPO4, 30.8% CaCO3, and 6.4% NaF. One part of TCS was combined with 9 parts of FA-CPC powder (FA-CPC with TCS). A 1.5 M phosphate solution was used as cement liquid. Setting time (ST), diametral tensile strength (DTS), phase composition by X-ray diffraction (XRD), and cement alkalinity were analyzed. Cement biocompatibility was assessed using rat subcutaneous model. Cement ST was 10.3±0.6 min and DTS was 3.89±0.76 MPa. XRD patterns showed that highly crystalline apatitic material was the only significant phase present and pH value was approximate 11.0. FA-CPC with TCS demonstrated similar biocompatibility as that of mineral trioxide aggregate control. These results suggest that FA-CPC with TCS may be useful for endodontic applications.