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HLA-DQw3 in Japanese Summer-type Hypersensitivity Pneumonitis Induced by Trichosporon cutaneum

1989; American Thoracic Society; Volume: 140; Issue: 4 Linguagem: Inglês

10.1164/ajrccm/140.4.948

2376-3752

Masayuki Ando, Kenji Hirayama, Kyosei Soda, Ryoko Okubo, Shukuro Araki, Takehiko Sasazuki,

IL-33, ST2, and ILC Pathways

The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum, and the results were compared with those obtained from 472 normal healthy subjects. Our results showed an increase in the frequency of HLA-DQw3 antigen in the patients (66% compared with 49% in the normal healthy control subjects: chi 2 = 5.48, p = 0.018, RR = 1.92), suggesting the importance of the host factors for the generation of this disease. The association between HLA-DQw3 as an immune suppression gene and the disease is discussed.