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Studies involving avermectin and the 4‐aminobutyric acid (GABA) receptor of Ascaris suum muscle

1988; Wiley; Volume: 24; Issue: 3 Linguagem: Inglês

10.1002/ps.2780240305

1096-9063

Lindy Holden‐Dye, Graham M. Hewitt, Kenneth T. Wann, Povl Krogsgaard‐Larsen, Robert Walker,

Insect Pest Control Strategies

Abstract This study describes the pharmacology of the Ascaris suum muscle GABA receptor using a range of GABA agonists and antagonists. The GABA receptor at this site does not readily fit into GABA‐A or GABA‐B classification. The effect of the potent anthehmintic, avermectin, on these cells was investigated. It was found to inhibit GABA‐evoked increase in membrane conductance and membrane hyper polarisation on quiescent muscle cells with an apparent affinity constant in the mid‐micromolar range. When applied to spontaneously active muscle cells, avermectin (I üM) inhibited the spiking activity after a delay of about 25 min.