Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes
1984; Elsevier BV; Volume: 120; Issue: 2 Linguagem: Inglês
10.1016/0006-291x(84)91283-x
ISSN1090-2104
AutoresFederico Leighton, Rosina Pérsico, Cecilia Necochea,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoThe production of hydrogen peroxide by isolated hepatocytes in response to lauric, palmitic and oleic acids, a measurement of peroxisomal fatty acid oxidation, is inhibited by phenothiazines under conditions in which ketone body production, a measurement of mitochondrial fatty acid oxidation, does not reveal inhibition of mitochondrial activity. This novel finding provides a pharmacological tool for the study of peroxisomal function in whole cells. The mechanism of this effect of phenothiazines, detected in hepatocytes from rats treated with a peroxisome proliferation inducing drug, is not yet known.
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