The influence of drying method on the physical properties of some graft copolymers for drug delivery systems
1997; Elsevier BV; Volume: 34; Issue: 1-2 Linguagem: Inglês
10.1016/s0144-8617(97)00057-x
ISSN1879-1344
AutoresIsabella Castellano, M. Gurruchaga, Isabel Goñi,
Tópico(s)Advanced Drug Delivery Systems
ResumoGraft copolymers of methyl methacrylate (MMA) on various natural substrates (carboxymethyl cellulose, hydroxypropyl cellulose, carboxymethyl starch and hydroxypropyl starch) were prepared in aqueous medium by the ceric ion initiator method. Products were dried in two differents ways: in ovens (O products) and by lyophilization (L products). The extent of graft copolymerization was measured in terms of grafting efficiency (GE), grafting (G), total conversion (CT) and crude grafting (CG). As would be expected, by both drying methods almost identical values of grafting yields were obtained. Using scanning electron microscopy (SEM) some morphological particle size differences between O and L products were observed. These differences lead to different physical properties (particle size, moisture uptake, density and swelling capacity) of O and L products.
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