Mating, channels and kidney cysts
1999; Nature Portfolio; Volume: 401; Issue: 6751 Linguagem: Inglês
10.1038/43810
ISSN1476-4687
AutoresScott W. Emmons, Stefan Somlo,
Tópico(s)Protist diversity and phylogeny
ResumoPeople with mutations in either of two proteins known as polycystin-1 and polycystin-2 develop polycystic kidney disease. Studies on the nematode worm and the frogXenopus laevisare now helping researchers to work out the normal functions of these proteins. It seems that polycystin-1-related proteins act as receptors, which regulate the activity of channels containing polycystin-2-related proteins.
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