The Office Tensilon Test for Ocular Myasthenia Gravis
1986; American Medical Association; Volume: 43; Issue: 8 Linguagem: Inglês
10.1001/archneur.1986.00520080081029
ISSN1538-3687
Autores Tópico(s)Myasthenia Gravis and Thymoma
ResumoThe technique for intravenous administration of Tensilon (edrophonium chloride) varies. In 1952, Osserman and Genkins 1 introduced the test and recommended a 2-mg initial dose followed, if no reaction (usually cholinergic) occurred in 45 s, by the rapid administration of an additional 8 mg. Others have modified the test by waiting five minutes after the initial dose, 2 by injecting Tensilon in small increments after the initial dose, 2-6 or by slowly infusing the remaining 8 mg. 5 Although I have recently been converted by Norman Schatz, MD, to the small-increment method, the significant controversy this essay should address is not drug administration but rather the test end point . What constitutes a "positive" Tensilon response in the physician's office where (without benefit of oculographic equipment 7-10 ) the first Tensilon test is performed in a suspected myasthenic? Such a determination is obviously important since a positive test is virtually diagnostic of
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