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Clinical Results of Radiation Therapy for Stage I Esophageal Cancer

2005; Lippincott Williams & Wilkins; Volume: 28; Issue: 1 Linguagem: Inglês

10.1097/01.coc.0000139021.91718.ee

1537-453X

Yoshiyuki Shioyama, Katsumasa Nakamura, T. Sasaki, Saiji Ooga, Yusuke Urashima, Masahiko Kimura, Satoru Uehara, Hiromi Terashima, Hiroshi Honda,

Esophageal and GI Pathology

From 1992 through 2001, 29 patients with stage I esophageal cancer were treated with radiation therapy. All patients had squamous cell carcinoma. Seventeen patients were treated with radiotherapy alone, and 12 were treated with a combination of chemotherapy and radiotherapy. Most of the chemotherapy regimens included cisplatin and/or 5-fluorouracil (5-FU). Twelve patients were treated with intracavitary irradiation (low-dose rate: 6, high-dose rate: 6) after external radiotherapy. Median fraction and total doses of external radiotherapy given were 2.0 Gy and 60.6 Gy, respectively. Median doses of intracavitary irradiation were 18 Gy/6 fractions in low-dose-rate brachytherapy and 13.5 Gy/4.5 fractions in high-dose-rate brachytherapy. The 5-year overall survival rate was 62%. The 5-year local control rate was 44%. Of the 29 patients, 9 had in-field recurrence in the esophagus and 1 had recurrence in the esophagus outside of the irradiated field. Of 9 patients with in-field local recurrence, 1 also developed mediastinal lymph node metastases and 1 had distant metastasis. Radiation therapy is an effective treatment modality for stage I esophageal cancer.