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Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis

2006; Springer Science+Business Media; Volume: 32; Issue: 2 Linguagem: Inglês

10.1007/s00134-005-0017-1

1432-1238

Evangelos J. Giamarellos–Bourboulis, Spyridon Zakynthinos, Fotini Baziaka, Evangelos Papadomichelakis, Simona Virtzili, Pantelis Koutoukas, Apostolos Armaganidis, Helen Giamarellou, Charis Roussos,

Intensive Care Unit Cognitive Disorders

To define the significance of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in the septic cascade by comparing its kinetics to those of other proinflammatory mediators and of interleukin (IL) 10.Prospective study in a tertiary unit.Blood was sampled from 90 patients with septic syndrome due to ventilator-associated pneumonia for 7 days after the appearance of symptoms. Concentrations of tumor necrosis factor (TNF) alpha, IL-6, IL-8, IL-10, and sTREM-1 were determined by enzyme-linked immunosorbent assay.Serum levels of TNFalpha, IL-6, IL-10, and sTREM-1 were higher in nonsurvivors than in survivors; similar differences were not found for IL-8. Positive correlations were found between the ratios IL-10/TNFalpha and sTREM-1/TNFalpha, between IL-10/IL-6 and sTREM-1/IL-6, and between IL-10/IL-8 and sTREM-1/IL-8. Median values of IL-10/TNFalpha upon presentation of sepsis, severe sepsis, and septic shock were 3.21, 2.16, and 2.86, respectively (NS). Respective values for sTREM-1/TNFalpha were 21.28, 7.33, and 27.78 (p=0.047 between sepsis and severe sepsis, p=0.003 between severe sepsis and septic shock).sTREM-1 follows the kinetics of IL-10 and should therefore be considered an anti-inflammatory mediator in sepsis. Decreased ratios of sTREM-1/TNFalpha might determine transition from sepsis to severe sepsis and from severe sepsis to septic shock.