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Pharmacokinetic Comparison of Two Albendazole Dosage Regimens in Patients with Neurocysticercosis

1993; Lippincott Williams & Wilkins; Volume: 16; Issue: 1 Linguagem: Inglês

10.1097/00002826-199302000-00009

1537-162X

Mónica Sánchez, Roberto Suástegui, Dinora F. González‐Esquivel, Julio Sotelo, Helgi Jung,

Parasites and Host Interactions

Summary To evaluate two different dosage regimens for albendazole (7.5 mg/ kg twice a day or 5.0 mg/kg three times a day), a study was performed in 10 patients with a diagnosis of parenchymal brain cysticercosis. Each patient received both regimens sequentially according to a randomized, crossover design. Blood and urine samples were taken once the drug steady state had been reached. Plasma levels of albendazole sulfoxide at steady state were determined using a HPLC method. In spite of a great intersubject variability observed with both regimens in the area under the curve (AUC) and in the minimum steady-state plasma concentration (Cp min ss), no statistically significant differences were found in these parameters. We suggest that a regimen of 7.5 mg/kg every 12 h can favorably replace the currently used regimen of 5 mg/kg every 8 h.